A Study on the Spectrum of Thyroid Abnormalities in Liver Disease and Its Correlation with Liver Function

Authors

  • Manju Sharma
  • Anju Mittal
  • Sangeeta Jain Sharma
  • Atul Kumar
  • Akshay Sharma
  • Yatin Kumar

DOI:

https://doi.org/10.37506/ijphrd.v14i4.18568

Keywords:

Child-Pugh-Turcott score, FT3,FT4 ,TSH,Chronic liver disease

Abstract

Introduction: liver diseases are associated with endocrine disturbances and secondary dysfunction of endocrine organ
which apparent hormonal imbalance. This study aims to find out the correlation between the levels of FT3, FT4, TSH and
severity of liver disease in Chronic Liver Disease patients.
Materials and Method: A total of 100 subjects with Chronic Liver disease satisfying inclusion and exclusion criteria
visiting medicine OPD and admitted in IPD of Muzaffarnagar Medical College during the period of 18 months was taken
for study which was a Cross Sectional Observational Study.Thyroid function tests which includes FreeT3, FreeT4, TSH
was done for all patients and tests such as Anti-TPO antibodies, USG neck, Doppler thyroid, FNAC thyroid was done
wherever indicated The liver function tests including total and direct bilirubin, total protein and albumin, AST and ALT,
APTT, PT, INR was done for all patients and USG abdomen and Oesophago-gastro-duodenoscopy was done wherever
indicated.
Results: The mean duration of liver disease in our study population was 5.92 ± 4.61 years (range 1-26 years). The mean
FT3 levelwas 2.3059 ± 0.8883 p Mol/L. The mean FT4 level was1.1689 ± 1.0806 ng/dL . The mean TSH level was 3.3198 ±
1.0173 m IU/mL The mean total bilirubin was 8.445 ± 4.3438 mg/dL .
Conclusion: Thyroid dysfunction forms important part of spectrum of Chronic liver disease. Patients with liver disease
should be evaluated for thyroid dysfunction periodically.

Author Biographies

Manju Sharma

Assistant Professor, Dept of biochemistry, Muzaffarnagar medical college

Anju Mittal

Associate Professor, Dept of Biochemistry, Muzaffarnagar medical college

Sangeeta Jain Sharma

Assistant Professor, Dept of Community Medicine, Muzaffarnagar Medical College

Atul Kumar

Associate Professor, Dept of Microbiology, Muzaffarnagar Medical College

Akshay Sharma

Assistant Professor, Dept of Medicine, Muzaffarnagar Medical College

Yatin Kumar

Senior Resident, Dept of Medicine, Muzaffarnagar Medical College

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Published

2022-10-10

How to Cite

Manju Sharma, Anju Mittal, Sangeeta Jain Sharma, Atul Kumar, Akshay Sharma, & Yatin Kumar. (2022). A Study on the Spectrum of Thyroid Abnormalities in Liver Disease and Its Correlation with Liver Function. Indian Journal of Public Health Research & Development, 13(4), 140–145. https://doi.org/10.37506/ijphrd.v14i4.18568