Give space between C and reactive Protein as an early Predictor of acute Pancreatitis: An Observational Study
Keywords:Amylase, Acute pancreatitis, C reactive protein, Pancreatic Necrosis
Background and Aim: In the early risk stratification of acute pancreatitis, C-reactive protein (CRP) is being used
extensively worldwide. There are few studies that show that CRP is useful in predicting pancreatic necrosis which is a
determinant of severe pancreatitis. Aim of the present study was to assess the role of CRP as a prognostic indicator in
Material and Methods: A total of 128 patients that were diagnosed to have acute pancreatitis were included in the study.
Data collected from the patient’s record (file/EMR) and organised in an Excel sheet that contained basic demographic
data (age and gender), cause, APACHE score, length of hospital/intensive care unit (ICU) stay and the CRP level. Blood
samples for CRP and biochemical markers for the APACHE II score were routinely drawn and processed on admission.
Results: The patients were divided into two groups, those with mild pancreatitis and those with severe acute pancreatitis.
Men were predominating in the study group where they contributed to 85.9% of the study population. Mean age of
presentation of acute pancreatitis was 37.7 years. Amylase and lipase were taken for the diagnosis of acute pancreatitis;
amylase and lipase were elevated significantly in 104 and 108 patients respectively. Twenty eight patients had an elevated
CRP > 150 in BISAP positive patients. There was significant association of CRP and BISAP.
Conclusion: Acute pancreatitis is a life-threatening disease with a wide spectrum of clinical symptoms. The job of
diagnostic markers as prognostic pointers has been a disappointment. However, CRP as a prognostic marker has shown
promising results in earlier studies.
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Copyright (c) 2022 Shivendra Dhakhda, Virendrakumar Dhakhada
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