Probiotics Efficacy and Safety as add-on Therapy to Metformin in Type 2 Diabetes Mellitus

Authors

  • Valishetti Manoj Kumar
  • Zoha Ahmed
  • Syed Atiq Ur Rahman

DOI:

https://doi.org/10.37506/ijphrd.v14i4.18637

Keywords:

Hyperglycaemia, Metformin, Probiotics, T2DM

Abstract

Background: Insulin secretion is decreased, and peripheral insulin sensitivity is diminished, resulting in type 2 diabetes
mellitus. Diet, oral antihyperglycemic medications, and insulin are all modalities for treatment.
Objective: The goal of this study was to compare the efficacy of probiotics as an add-on treatment to metformin in
patients with Type 2 Diabetes Mellitus.
Methods: The study participants were randomly allocated to one of two groups, Group A or Group B, using a computergenerated
randomization chart, with each group consisting of 75 patients. Group A - For 12 weeks, patients in this group
were administered Tab. Metformin 500 mg twice daily with meals. Group B - For 12 weeks, patients in this group were
administered Tab. Metformin 500 mg twice daily with meals and Cap. Probiotics 1 capsule twice daily with meals. At the
culmination of the second, fourth, eighth, and twelfth weeks, all patients were evaluated. Fasting and postprandial blood
glucose levels were measured at each visit. The HbA1c test was performed at the end of the 12th week.
Results: The male predominance was seen with males 57% and females 43% in the group A and the male : female ratio
was 1.34:1. In Group B males were 55% and females were 45%. The male: female ratio was 1.20 : 1. The mean HbA1C
slightly reduced since the start till the end of the study. A total of 37% of the patients experienced minor self-limiting side
effects in group A as compared to 6.66% of Group – B.
Conclusion: In treatment for type 2 diabetes mellitus, probiotics as an add-on therapy with metformin was observed
to lower fasting blood glucose, postprandial blood glucose, and HbA1c levels when compared to metformin alone. In
terms of effectiveness, probiotics have shown no substantial significant outcomes in combination therapy. However, the
probiotics study group had fewer reported gastrointestinal adverse effects associated with metformin treatment.

Author Biographies

Valishetti Manoj Kumar

PG MD Pharmacology, Osmania Medical College, Hyderabad

Zoha Ahmed

MBBS, Deccan College of Medical Sciences, Hyderabad

Syed Atiq Ur Rahman

Professor & Head, Department of Pharmacology, Government Medical College, Mahabubnagar.

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Published

2022-10-10

How to Cite

Valishetti Manoj Kumar, Zoha Ahmed, & Syed Atiq Ur Rahman. (2022). Probiotics Efficacy and Safety as add-on Therapy to Metformin in Type 2 Diabetes Mellitus. Indian Journal of Public Health Research & Development, 13(4), 317–321. https://doi.org/10.37506/ijphrd.v14i4.18637