Study of Pre-loading and Vasoconstrictors as Combined Prophylaxis for Hypotension During Sub-Arachnoid Anaesthesia

Abstract

Background: Hypotension following spinal anaesthesia is common physiological complications associated
with nausea, vomiting, dizziness aspiration, syncope and cardiac arrhythmias. Hence proper prophylaxis for
hypotension is essentialin lower abdominal and lower limb surgeries.
Method: Total sixty patients aged between 35 to 65 years undergoing lower abdominal and inferior extremities
were studied. Patients were randomly classified into three groups 20 patients in each group. Group-I patients
crystalloid group received RL and placebo. Group-II (Vasoconstrictor) group received Ephedrine and Group-III
(combination group) received RL (ringer lactate) and Ephedrine. Hemodynamic parameters and side effects of
each group was noted and compared.
Results: There was significant prophylaxis in all three groups at different intervals of 5, 10, 15, 20, 25 and 30
minutes (p<0.001) highly significant P and F values and 1 (5%) hypotension was observed in group-III, followed
by 4 (20%) in group-II and 9 (45%) highest hypotension in group-I and least side effects were also observed in
group-III patients.
Conclusion: It is concluded that group-III (combination groups) preloaded with RL solution and Ephedrine after
the injection of spinal anaesthetic drug proved ideal prophylaxis for hypotension during subarachnoid anaesthesia.