Comparative Study of Total Intravenous Anaesthesia Using Propofol with or without Sufentanil in Laparoscopic Cholecystectomies

Abstract

Background: Total intravenous anaesthesia (TIVA) is a ideal substitute to inhalation anaesthesia because of
hemodynamic complications. TIVA with suitable combination of anaesthetic drugs will have good post-operative
results.
Method: 60 patients aged between 18 to 65 years undergoing laparoscopic cholecystectomies were studied. Sixty
patients classified in three groups, 20 patients in each group. GroupsS1 and S2 received propofol with sufentanil
added at 1μgml and 2 μg ml concentration respectively while group P received propofol without sufentanil.
Additional sufentanil boluses (10 μg) were when there is an increase in the hemodynamic parameters, recovery
times, and post-operation analgesia g were compared in all three groups of patients.
Results: Hemodynamic parameters (HR, SBP, DBP) were not significantly different in all three groups. Fewer S2
patients required additional sufentanil boluses to maintain proper hemodynamic status. S2 group had better postoperative
analgesia (p<0.001) but prolonged recovery time as compared to other two groups.
Conclusion: Sufentanil mixed with propofol provides better hemodynamic stability in laparoscopic
cholecystectomies where more chances of pneumothoraxdue to fluctuations in hemodynamic parameters which
may lead to morbidity and mortality.