Evaluation of Oxidative stress using Superoxide Dismutase and Lipid Peroxidation in Lichen Planus: A Tissue Level Enzymatic Analysis Study

Abstract

Introduction: Oral Lichen Planus (OLP) is a chronic inflammatory disease of oral mucosa with unknown etiology.
Many studies have suggested that increased oxidative stress, an imbalance in the antioxidant defense system may
be involved in pathogenesis of Lichen planus.
Aim: The aim of this study was to compare the tissue levels of antioxidant Super oxide dismutase (SOD) and lipid
peroxidation marker Malondialdehyde (MDA) in established cases of OLP and healthy individuals.
Methodology: Ten patients with OLP and 10 control subjects matched for age and sex were enrolled in this case
control study. The tissue levels of SOD and MDA were measured both in case and control groups.
Results: The tissue levels of SOD were increased that was statistically significant in OLP patients compared to
healthy controls (p<0.01). The lipid peroxidation product MDA were relatively higher in OLP patients compared
to healthy controls. Conclusion: The current study suggests that oxidative damage is one of the major causes for
the pathogenesis of OLP.