Study of Pulmonary Function Tests in Rheumatoid Arthritis Patients and to Establish Correlation between Pulmonary Function and Disease Activity of Rheumatoid Arthritis in Eastern India

Authors

  • Biswajit Sarkar
  • Krishnachura Mitra
  • Deepak Chandra
  • Writtika Chattaraj
  • Sukanta Sen

DOI:

https://doi.org/10.37506/ijphrd.v14i3.19359

Keywords:

Rheumatoid arthritis (RA), DAS-28 disease activity score, pulmonary function test (PFT), rheumatoid factor, C-reactive protein, Anti-citrullinated protein antibody (ACPA)

Abstract

Background: Pulmonary involvement is one of the most common extra-articular manifestation of rheumatoid
arthritis (RA) and the second common cause of death due to infection. Pulmonary function tests are widely used
to provide objective measure of lung function for detecting and quantifying pulmonary impairments.
Material & Methods: This study was hospital based cross sectional nonintervention study. About 100 patients
of rheumatoid arthritis have been selected from Rheumatology Clinic (OPD) of R. G. Kar Medical College and
Hospital according to the ACR/EULAR diagnostic criteria, 2010. All patients were undergone for Hb% estimation,
ESR determination, estimation of serum RA-factor, C-reactive protein and ACPA. Disease Activity of RA had
determined by DAS-28 calculator. All cases and controls are undergone lung function test by means of electronic
spirometer in the Department of Physiology of the same institute.
Results: In our study 82% cases were female and 18% cases were males. In our study we got significant changes
in lung function of the RA patients. FVC, FEV1, PEFR and FEF 25-75% etc. were significantly deteriorated,
(p-value<0.0001). About 44% cases showed evidence of restrictive type of pulmonary function abnormality, it was
significant (p-value<0.05) whereas only 2% cases show evidence of obstructive type of abnormality, which was
not significant (p-value>0.05). There was definite correlation between disease duration and disease activity with
abnormal pulmonary function, (p-value<0.0001).
Conclusion: Therefore from the summary of this study, we can understand that lung function parameters can
be used to stratify abnormalities in a clinically useful manner and lung function tests can be used as indicator of disease activity of rheumatoid arthritis. So all patients of RA should undergo PFTs to detect abnormality and by this way we can reduce morbidity and mortality of RA patients due to subclinical or overt pulmonary dysfunction. 

Author Biographies

  • Biswajit Sarkar

    Assistant Professor, Department of Physiology, Midnapore Medical College, Vidyasagar Road, Paschim
    Medinipur, Midnapore, West Bengal

  • Krishnachura Mitra

    Assistant Professor, Department of Physiology, Nil Ratan Sircar Medical College & Hospital, Acharya Jagadish Chandra Bose Rd, Sealdah, Raja Bazar, Kolkata, West Bengal,

  • Deepak Chandra

    Assistant Professor, Department of Anaesthesiology, ICARE Institute of Medical Sciences and Research,
    Banbishnupur, Purba Medinipur, Haldia, West Bengal

  • Writtika Chattaraj

    Assistant Professor, Department of Physiology, Diamond Harbour Government Medical College & Hospital, Harindanga, Newtown, Diamond Harbour, South 24 Parganas, West Bengal

  • Sukanta Sen

    Professor & Head, Department of Pharmacology, ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal, India

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Published

2023-06-21

How to Cite

Study of Pulmonary Function Tests in Rheumatoid Arthritis Patients and to Establish Correlation between Pulmonary Function and Disease Activity of Rheumatoid Arthritis in Eastern India. (2023). Indian Journal of Public Health Research & Development, 14(3), 62-70. https://doi.org/10.37506/ijphrd.v14i3.19359