Immunohistochemical Expression of p16 and CDK4 in Soft Tissue Tumors

Abstract

Background: The large majority of soft tissue tumours are benign.Malignantmesenchymal neoplasms amount
to less than 1% of the overall human burden of malignant tumours but they are life threatening and may pose a
significant diagnostic and therapeutic challenge since there are more than 50 histological subtypes of STS, which
are often associated with unique clinical, prognostic and therapeutic features.
Methods: The study was undertaken in department of Pathology, King George’s Medical University, Lucknow.
The Study Design was Retrospective and prospective study carried over a period of one year from September 2018
to august 2019 including 70 cases.
Results: Most common diagnosis of malignant cases was Synovial saroma (21.4%) followed by Leiomyosarcoma
(19.0%) and Undifferentiated pleomorphic sarcoma & Fibromyxoid sarcoma (11.9% each). Less common diagnosis
were Ewing’s sarcoma, Liposarcoma and Rhabdomyosarcoma (9.5% each), 1 (2.4%) case each was diagnosed as
Chondrosarcoma, MPNST and Myxoid liposarcoma.
Conclusions: Genetic alterations involving the 12q13-15 chromosomal region are common in musculoskeletal
sarcomas, and many bone and soft-tissue malignant tumors showed amplification of various genes located in this
region