Impact of Diabetes Mellitus on Spectrum of Presentation of Tuberculosis

Authors

  • Jyotirmoy Ghanta
  • Buddhadev Panja
  • Bibhuti Bhushan
  • Kausik Maji
  • Somenath Kundu
  • Sukanta Sen

DOI:

https://doi.org/10.37506/ijphrd.v14i3.19368

Keywords:

: Tuberculosis, Diabetes mellitus, clinic-radiological presentations, TB Symptom Score, TB Severity Score

Abstract

Introduction: Increased occurrence of tuberculosis in diabetic population is known since long time. Tuberculosis
(TB) remains one of the world’s deadliest communicable diseases and India currently bears the highest burden of
tuberculosis in the World. Diabetes mellitus (DM) is becoming the epidemic of the 21st century with India having
the second largest diabetic populationglobally. This emphasizes the importance of investigating the association of
tuberculosis and diabetes mellitus.
Aim: To evaluate clinic-radiological presentations of tuberculosis (pulmonary and extra pulmonary) in diabetic
patients compared to non-diabetic patients.
Materials and Methods: Patients with active tuberculosis with and without diabetes mellitus were enrolled and
the two groups were matched for age, sex, addiction habits, history of contact with tuberculosis and previous
treatment for tuberculosis. Spectrums of tubercular involvement in both the groups were studied including
severity of the disease. A symptom score comprising major TB related symptoms and a composite severity score
utilizing clinical, radiological, and microbiological parameters were used to compare TB severity between the two
groups.
Results: Patients with TB with DM were found to have male preponderance (70%), higher BMI, increased chance
of having isolated lower lobe lesion (8%), multilobar lesion (42%) and cavitary lesion (20%), significantly higher
TB symptom score and TB severity score compared to patients with TB without DM. The TB severity score has
significant correlation with level of HbA1c at presentation.
Conclusion: Presence of coexistent diabetes along with tuberculosis results in increased severity of tuberculosis
and its severity has direct correlation with poor glycemic status at presentation.

Author Biographies

Jyotirmoy Ghanta

Assistant Professor, Department of Respiratory Medicine ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, W.B

Buddhadev Panja

Assistant Professor, Department of Pharmacology, ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia,W.B.,

Bibhuti Bhushan

Associate Professor, Department of General Medicine, Gouri Devi Institute of Medical Sciences
& Hospital, Rajbandh, Durgapur, W.B.

Kausik Maji

Professor & Head, Department of General Medicine, ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia

Somenath Kundu

Professor and Head,Department of Respiratory Medicine, Institute of Post Graduate Medical Education and Research, Kolkata,

Sukanta Sen

Professor & Head, Department of Pharmacology, ICARE Institute of Medical Sciences and Research,
Banbishnupur, Purba Medinipur, Haldia, West Bengal, India

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Published

2023-06-21

How to Cite

Jyotirmoy Ghanta, Buddhadev Panja, Bibhuti Bhushan, Kausik Maji, Somenath Kundu, & Sukanta Sen. (2023). Impact of Diabetes Mellitus on Spectrum of Presentation of Tuberculosis. Indian Journal of Public Health Research & Development, 14(3), 111–117. https://doi.org/10.37506/ijphrd.v14i3.19368

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