Analysis of Programmed Death- Ligand 1 Expression in Urothelial Carcinoma

Abstract

Background: Urothelial bladder cancer is a disease of significant morbidity and mortality. It is ninth most
common malignancy worldwide. It is the 7th most common cancer worldwide in men and the 17th most common
cancer worldwide in women.Methods: The present study was undertaken in the Department of Pathology, King
George’s Medical University, Lucknow in collaboration with The Department of Urology, King George’s Medical
University, Lucknow, after getting approval from Institutional Ethical Committee. Samples were collected from
the department of urology with their clinical details. The study design was Retrospective and Prospective Crosssectional study
Results: Majority of the cases were Conventional UC (83.8%), other common types were Squamoid, Glandular
and Signet ring (5.0%, 6.3% & 2.5%). Apart from these, 1 (1.3%) case each was differentiated as Sarcomatoid and
Sarcomatoid with glandular variant.
Conclusions: Majority of cases with tumour recurrence showed strong positive PD-L1 expression and this
association was found to be significant suggesting that degree of PD-L1 expression may be a crucial determinant
of tumour invasiveness not only for primary tumours but also for recurrent tumours