Can Uric Acid be Used as a Surrogate for Urinary Albumin in Type-2 Diabetes? A Prospective Observational Study

Abstract

Background: Elevated serum uric acid and increased urinary albumin excretion are manifestations of common
underlying pathogenesis of insulin resistance.The present study explores the relationship between uric acid level
and urinary albumin in diabetic patients.
Methods: A prospective cross-sectional study was carried out in 100 diabetes patients attending
BharatiVidyapeethHospital, Pune. Midstream urine spot test and urinary albumin-creatinine ratio (ACR)
along with serum uric acid, fasting blood glucose (FBG), cholesterol, triglyceride, high-density lipoprotein
cholesterol(HDLC), low density lipoprotein cholesterol (LDLC), albumin, and creatinine levels were estimated.
Conclusion: A significant association was observed between uric acid levels with duration of diabetes more than
10 years in presence of dyslipidemia and poor glycemia control (P value 0.05). On multivariate regression analysis,
serum uric acid (OR - 2.498;1.51-4.12) and duration of the diabetes (OR - 1.258: 1.049-1.51) were observed to be
significant predictors of Albumin-Creatinine ratio. The present study strongly suggests a close link between uric
acid and increased urinary albumin excretion rate in type 2 diabetic patients.