Determination of Insulin Resistance and Dyslipidemia after treatment with selective Anti-Depressants in case of Major Depression
Keywords:Major Depressive disorder, glycemic index, HOMA-IR, Dyslipidemia,SSRI
Introduction: Depression can present a plethora of symptoms, such as loss of pleasure, feelings of guilt, low self
esteem, and disturbed sleep or appetite. Selective Serotonin Re-uptake Inhibitors (SSRIs) are considered as the
mainstay of treatment for depression. Several studies suggest that antidepressants increase the risk of developing
metabolic complications including Insulin Resistance (IR) and dyslipidemia, thus leading to poor health outcomes.
This study would provide a review of depression and IR and examine side effects of anti-depressants that are often
used to treat depression.
Material & Methods: It was a cross-sectional analytical study conducted at the Department of Biochemistry,
College of Medicine and Sagore Dutta Hospital, in collaboration with Department of Psychiatry. Patients attending
the psychiatric OPD, who are newly diagnosed as Major Depressive Disorder (MDD) orrecurrent depressive
disorder were selected. Age and gender matched healthy family members of the patients were chosen as controls.
Results: Significant alteration of Body Mass Index (BMI), Hamilton Depression Scaling (HAM-D), High Density
Lipoprotein (HDL) and Low Density Lipoprotein (LDL )with non-significant variation of HOMA-IR, Total
Cholesterol and Triglyceride levels were found
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