Determination of Insulin Resistance and Dyslipidemia after treatment with selective Anti-Depressants in case of Major Depression

Authors

  • Somsubhra Chattopadhyay
  • Sharmistha Debnath
  • Sudeshna Ray
  • Satwika Sinha

DOI:

https://doi.org/10.37506/ijphrd.v14i3.19427

Keywords:

Major Depressive disorder, glycemic index, HOMA-IR, Dyslipidemia,SSRI

Abstract

Introduction: Depression can present a plethora of symptoms, such as loss of pleasure, feelings of guilt, low self
esteem, and disturbed sleep or appetite. Selective Serotonin Re-uptake Inhibitors (SSRIs) are considered as the
mainstay of treatment for depression. Several studies suggest that antidepressants increase the risk of developing
metabolic complications including Insulin Resistance (IR) and dyslipidemia, thus leading to poor health outcomes.
This study would provide a review of depression and IR and examine side effects of anti-depressants that are often
used to treat depression.
Material & Methods: It was a cross-sectional analytical study conducted at the Department of Biochemistry,
College of Medicine and Sagore Dutta Hospital, in collaboration with Department of Psychiatry. Patients attending
the psychiatric OPD, who are newly diagnosed as Major Depressive Disorder (MDD) orrecurrent depressive
disorder were selected. Age and gender matched healthy family members of the patients were chosen as controls.
Results: Significant alteration of Body Mass Index (BMI), Hamilton Depression Scaling (HAM-D), High Density
Lipoprotein (HDL) and Low Density Lipoprotein (LDL )with non-significant variation of HOMA-IR, Total
Cholesterol and Triglyceride levels were found

Author Biographies

  • Somsubhra Chattopadhyay

    Associate Professor, Department of Psychiatry, College of Medicine & Sagore Dutta Hospital,
    Kamarhati, Kolkata

  • Sharmistha Debnath

    Associate Professor, Department of Oncopathology, Medical College & Hospital, Kolkata,

  • Sudeshna Ray

    Demonstrator, Department of Biochemistry, College of Medicine & Sagore Dutta Hospital,
    Kolkata,

  • Satwika Sinha

    Associate Professor, Department of Biochemistry, College of Medicine & Sagore Dutta Hospital,
    B.T Road Kamarhati, Kolkata

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Published

2023-06-21

How to Cite

Determination of Insulin Resistance and Dyslipidemia after treatment with selective Anti-Depressants in case of Major Depression. (2023). Indian Journal of Public Health Research & Development, 14(3), 342-346. https://doi.org/10.37506/ijphrd.v14i3.19427