Early Diagnosis of Typhoid Fever: Uses of Clinical Profile, Blood Culture and IGM Antibody: A Prospective Study from a Tertiary Care Centre in Western Uttar Pradesh

Editor's Note: This article has been retracted as of January 2026 as it is out of scope

Abstract

Objective:
• To study clinical profile of typhoid in children.
• To study Comparison of clinical profile and its correlation with blood culture and IgM antibody detection test
for early diagnosis of fever.
• To study blood culture and widal at tertiary care centre in western UP.
Methods: The study was carried out in Department of Pediatrics, Saraswathi Institute of Medical Sciences, Hapur,
UP. All the children presenting with fever, aged from 6 months to 18 years, visited in the pediatric OPD(outpatient
department) and IPD(in patient department) of Saraswathi Institute of Medical Sciences from November 2020 to
October 2022 were included in the study.
Results: IgM antibody test was found positive in total 167 cases and negative in 63 cases. Also, blood culture was
reported positive in 157 cases and negative in 73 cases. Out of total positive IgM antibody, 138 showed positive
for blood culture and 29 were reported negative in blood culture. Out of total negative IgM antibody, 19 showed
positive for blood culture and 44 were reported negative in blood culture.
Conclusion: Present study shows that typhoid IgM procedure is more sensitive than the established Widal
agglutination assay and results can be obtained within 15 minutes while widal agglutination test can be done
after 1 week. Typhi IgM test can be done after 72 hours of illness as IgM antibody becomes positive after 3 days of
infection with Salmonella typhi. It is cost effective and can be done bed side.