Diagnostic Importance of Clinic-Pathologic Features and p16, CD34, MDM2 Expression in Differential Diagnosis of Tumors

Abstract

Background: The large majority of soft tissue tumors are benign. Malignant mesenchymal neoplasm amount to
less than 1% of the overall human burden of malignant tumors but they are life threatening and may pose a
significant diagnostic and therapeutic challenge since there are more than 50 histological subtypes of STS, which
are often associated with unique clinical, prognostic and therapeutic features.
Methods: The study was undertaken in department of Pathology, King George’s Medical University, Lucknow.
The Study Design was Retrospective and prospective study carried over a period of two year from September
2018 to august 2020 including 70 cases. Results. Most common diagnosis of malignant cases was Synovial saroma
(21.4%) followed by Leiomyosarcoma (19.0%) and Undifferentiated pleomorphic sarcoma & Fibromyxoid sarcoma
(11.9% each). Less common diagnosis were Ewing’s sarcoma, Liposarcoma and Rhabdomyosarcoma (9.5% each),
1 (2.4%) case each was diagnosed as Chondrosarcoma, MPNST and Myxoid liposarcoma.
Conclusions: Genetic alterations involving the 12q13-15 chromosomal region are common in musculoskeletal
sarcomas, and many bone and soft-tissue malignant tumors showed amplification of various genes located in this
region.