Assessment of Cobalt Binding Activity of Albumin in COVID-19 Patients and its Correlation with CRP
DOI:
https://doi.org/10.37506/775kfp65Keywords:
C reactive protein, Covid 19, Cobalt Binding activity.Abstract
Background: Covid 19 pandemic has thrown a big challenge in terms of available manpower, space and financial recourses at all levels of healthcare facilities. The disease manifestation ranges from asymptomatic to severe but a pro-inflammatory milieu is the underlying ongoing event. Detection of pro- inflammatory markers in early stages of the disease is instrumental to avert future complications.
Method: For the present study 35 RT-PCR positive Covid patients were chosen from indoor admissions along with 35 age and sex matched controls. C Reactive Protein (CRP) and cobalt binding activity of albumin measured in both groups and compared statistically.
The values of CRP is elevated in cases (153.92± 87.56) as compared to controls (3.71± 3.07) which is statistically significant (p value= 0.001).Elevation of Cobalt binding activity of albumin is statistically significant (p value=0.0001) in cases (151.04± 37.38) when compared to controls (81.96± 29.49). Moreover elevation of cobalt binding activity of albumin bears moderate positive correlation (r=0.609) with the elevation of CRP levels.
Conclusion: As laboratory assay of cobalt binding albumin has manifold advantages, when compared to assay of CRP, the former may emerge as a promising marker if similar result are obtained with a larger study population.
References
Zhang C, Wu Z, Li J-W, Zhao H, Wang G-Q. Cytokine
release syndrome in severe COVID-19: interleukin-6
receptor antagonist tocilizumab may be the key
to reduce mortality. Int J Antimicrob Agents. 2020
May;55(5):105954.
Pal S, Sengupta S, Osta M. Role of C-reactive protein,
serum ferritin, albumin, and lactate dehydrogenase in
hospitalized coronavirus disease-19 infected patients –
A study in tertiary care coronavirus disease-19 center
in Eastern India. Natl J Physiol Pharm Pharmacol.
(2021), [cited February 04, 2022]; 11(4): 441-443.
Müller W, Mierau R, Wolhtmann D. Interference of
IgM rheumatoid factor with nephelometric C-reactive
protein determinations. Journal of Immunological
methods.1985 Jun;80(1):77-90.
Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt–
albumin binding and its potential as a marker for
myocardial ischemia: a preliminary report. J Emerg
Med. 2000;19:311–315
Chen N, Zhou M, Dong X et al. Epidemiological
and clinical characteristics of 99 cases of 2019 novel
coronavirus pneumonia in Wuhan, China: a descriptive
study. Lancet 2020;395:507–13.
Liu F, Li L, Xu M et al. Prognostic value of interleukin-6,
C-reactive protein, and procalcitonin in patients with
COVID-19. J ClinVirol2020;127:104370.
Immanuel S, Sanjaya AI. Albumin Cobalt Binding (ACB)
Test: Its Role as a Novel Marker of Acute Coronary
Syndrome. Acta Med Indones-Indones. 2006;38:92–96.
Chawla R, Goyal N, Calton R, Goyal S. Ischemia
Modified Albumin: A novel marker for acute
coronary syndrome. Indian Journal of Clinical
Biochemistry. 2006;21:77–82.
Christenson RH, Duh SH, Sanhai WR, Wu AH,
Holtman V, Painter P, Branham E, Apple FS,
Murakami M, Morris DL. Characteristics of an
albumin cobalt binding test for assessment of acute
coronary syndrome patients: a multicenter study. Clin
Chem. 2001;47:464–470.
Bhagavan NV, Lai EM, Rios PA, Yang J, Ortega-Lopez
AM, Shinoda H, Honda SA, Rios CN, Sugiyama CE, Ha
CE. Evaluation of human serum albumin cobalt binding
assay for the assessment of myocardial ischemia and
myocardial infarction. Clin Chem. 2003;49:581–585.
Duarte Marta MMF, Rocha João BT, Rafael NM,
Thiago D, Da CruzI BM, Loro VL, Schetinger
MRC. Association between ischemia- modified
albumin, lipids and inflammation biomarkers
in patients with hypercholesterolemia. Clinical
Biochemistry. 2009;42:666–671. 2009.
Ghosh K, Muddeshwar MG, Lokhande M, Ghosh
K. lAbumin Cobalt Binding or Ischaemia Modified
Albumin: A test of great prognostic value in
malaria. Mediterr J Hematol Infect Dis. 2017 Jun
;9(1):e2017041.
Gupta RK, Michael Marks M, Samuels THA et al.
Systematic evaluation and external validation of 22
prognostic models among hospitalized adults with
COVID-19: An observational cohort study. EurRespir
J 2020;56:2003498.
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