Usefulness of Umbilical Cord Nucleated RBC as a Prognostic Marker of Neonate Born to Pregnancy Induced Hypertension Mother in Resource Limiting Settings
DOI:
https://doi.org/10.37506/rna8ab55Keywords:
Asphyxia, Pregnancy induced hypertension, Hypoglycemia, Respiratory distress.Abstract
Background: Pregnancy induced hypertension are multi-system disorders of the mother that affect the fetus
because of utero-placental insufficiency. These neonates may also have a spectrum of hematological changes which may add to the existing morbidity in them. objectives: To correlate cord Nucleated red blood cells and neonatal outcome in Pregnancy induced hypertension.
Materials and method: The study was conducted in the Mata Chanan Devi Hospital, Janakpuri, New Delhi. A total of 55 cases and 55 controls of newborns fulfilling the inclusion criteria. The mother’s antenatal records were examined to rule out the Pre-Existing maternal medical illness. History of drug intake and compliance
of treatment was recorded. Results: Cord blood nucleated red blood cells was significantly raised in
neonates born to PIH mothers (>13 NRBC/100 WBC) compared to normotensive mothers and also had
significantly higher incidence of Low birth weight, Hypoglycemia, Respiratory distress and Asphyxia.
Conclusion: NRBC count can be used as a simple tool where expertise not available and accordingly can plan the interventions. It is a special boon in a rural care center, where advanced diagnostic modalities are unaffordable or inaccessible. Umbilical cord NRBC count it correlates well with neonatal outcome.
References
Dorling J.S, Field D.J, Manktelow B. Neonatal disease
severity scoring systems. Arch. Dis. Child. Fetal
Neonatal Ed. 2005;90:F11–F16.
Richardson D.K, Corcoran J.D, Escobar G.J, Lee
S.K. SNAP-II and SNAPPE-II: Simplified newborn
illness severity and mortality risk scores. J Pediatr.
;138:92– 100.
Janota J, Stranák Z, Statecná B, Dohnalová A, Sípek
A, Simák J. Characterization of multiple organ
dysfunction syndrome in very low birthweight infants:
A new sequential scoring system. Shock. 2001;15:348–
Parry G, Tucker J, Tarnow-Mordi W. CRIB II: An
update of the clinical risk index for babies score.
Lancet. 2003;361:1789-91.
Goel M, Dwivedi R, Gohiya P, Hegde D. Nucleated
red blood cell in cord blood as a marker of perinatal
asphyxia. J Clin Neonatol. 2013;2:179–182.
Boskabadi H, Zakerihamidi M, Sadeghian M.H, Avan
A, Ghayour-Mobarhan M, Ferns
G.A. Nucleated red blood cells count as a
prognostic biomarker in predicting the complications
of asphyxia in neonates. J. Matern. Fetal Neonatal Med.
;30:2551-6.
Sharma D, Farahbakhsh N, Shastri S, Sharma P.
Biomarkers for diagnosis of neonatal sepsis: A
literature review. J. Matern. Fetal Neonatal Med.
;31:1646-59.
Bhandari V. Elective Biomarkers for Diagnosis of
Neonatal Sepsis. J Pediatr Infect Dis Soc. 2014;3:234-45.
Hadzimuratovic E, Skokic F, Hadzimuratovic A,
Nazdrajic A, Mujic M, Hadzimuratovic
A. Acute renal failure in term newborn following
perinatal asphyxia. Sanamed. 2017;12:11.
Christensen R.D, Henry E, Andres R.L, Bennett S.T.
Reference ranges for blood concentrations of nucleated
red blood cells in neonates. Neonatology. 2011;99:289-
Stachon A, Segbers E, Holland-Letz T, Kempf R,
Hering S, Krieg M. Nucleated red blood cells in the
blood of medical intensive care patients indicate
increased mortality risk: A prospective cohort study.
Crit Care. 2007;11:R62.
Menk M, Giebelhäuser L, Vorderwülbecke G, Gassner
M, Graw J.A, Weiss B, Zimmermann M,Wernecke
K.-D,Weber-Carstens S. Nucleated red blood cells as
predictors of mortality in patients with acute respiratory
distress syndrome (ARDS): An observational study.
Ann. Intensive Care. 2018;8:42.
Boskabadi H, Maamouri G, Sadeghian M, Ghayour-
Mobarhan M, Heidarzade M, Shakeri M.-T, Ferns G.
Early Diagnosis of Perinatal Asphyxia by Nucleated
Red Blood Cell Count: A Case-control Study. Arch Iran
Med. 2010;13:275-81.
Christensen R.D, Lambert D.K, Richards D.S.
Estimating the nucleated red blood cell ‘emergence
time’ inneonates. J Perinatol. 2014;34:116-9.
Boskabadi H, Ashrafzadeh F, Doosti H, Zakerihamidi
M. Assessment of risk factors and prognosis in
asphyxiated infants. Iranian journal of pediatrics.
;25(4).
UNICEF. State of the World’s Children: Celebrating
Years of the Convention on the Rights of the Child:
Unicef; 2009. Martin RJ, Fanaroff AA, Walsh MC.
Neonatal- perinatal medicine: diseases of the fetus and
infant: Elsevier/Mosby; 2011.
Martin RJ, Fanaroff AA, Walsh MC. Neonatal-perinatal
medicine: diseases of the fetus and infant: Elsevier/
Mosby; 2011.
Green DW, Mimouni F. Nucleated erythrocytes in
healthy infants and in infants of diabetic mothers. The
Journal of pediatrics. 1990;116(1):129-31.
Hermansen MC. Potential for brief but severe
intrapartum injury among neonates with early-onset
seizures and elevated nucleated red blood cell counts.
American journal of obstetrics and gynecology.
;184(4):782.
Young SA, Crocker DW. Occult congenital syphilis in
macerated stillborn fetuses. Archives of pathology &
laboratory medicine. 1994;118(1):44-7.
AL-Bayati MM, Jameel BZ, Suhial TM, Melkon AA.
Maternal and Cord Blood Nucleated Red Blood Cells
Count in Women with Preeclampsia. Iraqi J Comm
Med. 2011;24 (4):302-7.
Gasparovic VE, Ahmetasevic SG, Colic A. Nucleated
red blood cells count as first prognostic marker for
adverse neonatal outcome in severe preeclamptic
pregnancies. CollAntropol. 2012;36(3):853–7.
Krishna P, Karthik R, Adarsh E.Significance of cord
blood nucleated red blood cell count in pregnancies
complicated by preeclampsia as a marker for intra
uterine growth restriction. Int J Contemp Pediatr
;7:1723-7
Ghosh B, Mittal S, Kumar S, Dadhwal V. Prediction
of perinatal asphyxia with nucleated red blood cells
in cord blood of newborns. Int J GynaecolObstet
;81(3): 267-71.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.