Taste Dysfunction and its Relationship to HbA1C Level and Disease Duration in Type 2 Diabetes Mellitus Patients with Autonomic Neuropathy
DOI:
https://doi.org/10.37506/xvyy2b07Keywords:
HbA1C, Neuropathy, Taste Dysfunction, Type 2 diabetes mellitus.Abstract
Background and Aim: Type 2 diabetes mellitus (T2DM) effect quality of life very much and causes various
complications. Diabetic autonomic neuropathy (DAN) is one of the common complications in diabetes. Thus
present study was aimed at determining taste dysfunction in a population of T2DM subjects and its correlation with HbA1c level.
Material and Methods: This was an observational cross sectional study which was carried over a period of one year in the department of medicine, Tertiary care institute of India. The 100 patients of T2DM with autonomic
neuropathy and 100 healthy controls were taken for the study. Autonomic neuropathy was assessed clinically.
Chemical taste test using four solutions of basic tastes (sweet, sour, salty, bitter) were done.
Results: There was a significant difference between the 2 groups in terms of HbA1c (%) (p≤0.05), with the median HbA1c (%) being highest in the chemical taste dysfunction: sweet: yes group. Strength of association (Point- Biserial correlation)=0.49. There was a significant difference between the various groups in terms of distribution of chemical taste dysfunction: Sweet (p≤0.05). There was no significant difference between the groups in terms of duration of T2DM (years) (p>0.05).
Conclusion: The study found a significant correlation between taste dysfunction and HbA1C level and blood
sugar fasting level in type 2 diabetes mellitus patients. Alteration in taste was mainly for sweet. Sour, and bitter did not show any difference in case groups compared to controls.
References
American Diabetes Association. Classification and
diagnosis of diabetes: standards of medical care in
diabetes-2020. Diabetes Care 2020;43:S14–31.
DeFronzo RA, Ferrannini E, Groop L, Henry RR,
Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman
GI, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers
;1:15019.
Forbes, J.M.; Cooper, M.E. Mechanisms of diabetic
complications. Physiol. Rev. 2013, 93, 137–188.
[CrossRef] [PubMed]
Barragan, R, Coltell, O, Portoles O. Asensio E.M. Sorli,
J.V, Ortega-Azorin, C. et al. Bitter, Sweet, Salty, Sour
and Umami Taste Perception Decreases with Age:
Sex-Specific Analysis, Modulation by Genetic Variants
and Taste-Preference Associations in 18 to 80 Year-Old
Subjects. Nutrients 2018, 10, 1539.
Forbes, J.M.; Cooper, M.E. Mechanisms of diabetic
complications. Physiol. Rev. 2013, 93, 137–188.
Narukawa M. Physiological responses to taste signals
of functional food components. Biosci Biotechnol
Biochem. 2018;82:200-6.
Douglas JE, Mansfield CJ, Arayata CJ, Cowart BJ,
Colquitt LR, Maina IW et al. Taste Exam: A Brief and
Validated Test. J Vis Exp. 2018;(138):e56705.
Kikut-Ligaj, D.; Trzcielinska-Lorych, J. How taste
works: Cells, receptors and gustatory perception. Cell.
Mol. Biol. Lett. 2015, 20, 699–716. [CrossRef]
Tan, S.Y.; Tucker, R.M. Sweet Taste as a Predictor of
Dietary Intake: A Systematic Review. Nutrients 2019,
, 94.
Chochinov RH, Ullyot GL, Moorhouse JA. Sensory
perception thresholds in patients with juvenile diabetes
and their close relatives. N Engl J Med. 1972;286:1233-7.
Gondivkar SM, Indurkar A, Degwekar S, Bhowate
R. Evaluation of gustatory function in patients
with diabetes mellitus type 2. Oral Surg Oral Med.
;108:876-80.
Bustos-Saldaña R, Alfaro-Rodríguez M, De la Luz
Solís-Ruiz M, Trujillo-Hernández B, PachecoCarrasco
M, Vázquez-Jiménez C. Taste sensitivity diminution in
hyperglycemic type 2 diabetics patients. Rev Med Inst
Mex Seguro Soc. 2009;47:483-8.
Bustos-Saldaña, R.; Alfaro-Rodríguez, M.; de la Luz
Solís-Ruiz, M.; Trujillo-Hernández, B.; Pacheco-
Carrasco, M.; Vázquez-Jiménez, C. Taste sensitivity
diminution in hyperglycemic type 2 diabetics patients.
Rev. Med. Inst. Mex. Seguro Soc. 2009, 47, 483–488.
Tan, S.Y.; Tucker, R.M. Sweet Taste as a Predictor of
Dietary Intake: A Systematic Review. Nutrients 2019,
, 94.
Sergi, G.; Bano, G.; Pizzato, S.; Veronese, N.; Manzato,
E. Taste loss in the elderly: Possible implications for
dietary habits. Crit. Rev. Food Sci. Nutr. 2017, 57, 3684–
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