Coagulation Dysfunction and Inflammatory Storm in Post Covid -19, An Observational Cross Sectional Study

Abstract

Background-The world was struggling in lockdown for months since December of 2019 due to novel coronavirus disease (COVID-19) outbreak, a pandemic declared by the World Health Organization . Research evidence is growing on the role of several symptoms, comorbidities, inflammation and hypercoagulability markers in relation to disease progression and deaths in COVID-19 patients. The incidence of diabetes, one of the leading causes of morbidity has been shown to be high and is associated with disease progression in COVID-19. More than 425 million individuals have diabetes worldwide and projections show this number rising to
629 million by 2045. This Study was done with fallowing objectives-To compare markers of coagulation dysfunction and markers of inflammation in Diabetic and Non-Diabetic Post COVID-19 patients.

Material and method-This is an observational cross -sectional study assessing Post COVID- 19 . In this study among 214 patients participated, in which 129 patients were diabetic and 85 patients were non- diabetic.

Result- The following variables were significantly associated (p<0.05) with the diabetic Post COVID-19 patients: Age (Years), TLC (/cu.mm), S.Ferritin (ng/mL), S.Procalcitonin (ng/mL), D-Dimer (µg/mL), S.LDH (U/L), SpO2 (%), FBS (mg/dL), PPBS (mg/dL), A1c
(%), PT (Sec), aPTT (Sec), INR
Conclusion- The presence of diabetes could further influence the magnitude of inflammatory and coagulation dysfunction in Post COVID-19. Strikingly, a recent study showed a significant increase in these markers in diabetic group as compared to non-diabetic group of Post-COVID-19 patients without other comorbidities, indicating the independent impact of diabetes..