Association of Cytological and Biochemical Parameters with Pleural Effusion in Patients Attending a Tertiary Care Hospital of Western U.P.

Authors

  • Siddharth Kumar Associate Professor, Dept. of Respiratory Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P
  • Vibha Nimesh Assistant Professor, Dept. of Radio-diagnosis Saraswathi Institute of Medical Sciences, Hapur. U.P
  • Lalit Garg Senior Resident, Dept. of Respiratory Medicine Saraswati Institute of Medical Sciences, Hapur. U.P
  • Shubham Kumar Sharma Statistician, Dept. of Community Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P
  • Vishwanath Ghoshal Assistant Professor, Dept. of Community Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

DOI:

https://doi.org/10.37506/6nkafs72

Keywords:

Pleural effusion, ADA, Cytological, Biochemical, Lymphocytes, Neutrophils.

Abstract

Background

Pleural effusion is the pathological accumulation of fluid in the pleural space.This study was done to assess the association of cytological, biochemical, radiological and microbiological parameters in the evaluation of pleural effusion.

Materials and Methods

Present study was done in Saraswathi Institute of Medical Sciences- OPD/IPD of Respiratory Medicine department. As per the inclusion /exclusion criteria the study included 70 participants. Ethical clearance was taken before the commencement of study. Data was analyzed using SPSS software version 26.

Majority of participants in present study were males. Majority belongs to age group 19-29 years with mean age was found to be 34.93 ± 12.99 years. Majority of patients had exudative type of pleural effusion. Lymphocytes was found to be higher as compare to neutrophils and other cells in Tubercular cases than Non-TB cases. Similar findings were found in other studies too.

Conclusion

The present study suggest that a high fluid ADA is a vital diagnostic tool and suggest its usage as a quick diagnostic method to diagnose Tuberculous Pleural Effusion.

Author Biographies

  • Siddharth Kumar, Associate Professor, Dept. of Respiratory Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

    Associate Professor, Dept. of Respiratory Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

  • Vibha Nimesh, Assistant Professor, Dept. of Radio-diagnosis Saraswathi Institute of Medical Sciences, Hapur. U.P

    Assistant Professor, Dept. of Radio-diagnosis Saraswathi Institute of Medical Sciences, Hapur. U.P

  • Lalit Garg, Senior Resident, Dept. of Respiratory Medicine Saraswati Institute of Medical Sciences, Hapur. U.P

    Senior Resident, Dept. of Respiratory Medicine Saraswati Institute of Medical Sciences, Hapur. U.P

  • Shubham Kumar Sharma, Statistician, Dept. of Community Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

    Statistician, Dept. of Community Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

  • Vishwanath Ghoshal, Assistant Professor, Dept. of Community Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

    Assistant Professor, Dept. of Community Medicine Saraswathi Institute of Medical Sciences, Hapur. U.P

References

Jany B, Welte T. Pleural Effusion in Adults-Etiology, Diagnosis, and Treatment. Dtsch Arztebl Int. 2019;116(21):377-386. doi:10.3238/arztebl.2019.0377

Sundaralingam A, Bedawi EO, Rahman NM. Diagnostics in Pleural Disease. Diagnostics (Basel, Switzerland). 2020;10(12). doi:10.3390/diagnostics10121046

Ramaswamy DA. Significance of Adenosine Deaminase Levels in Diagnosis of Pleural Effusion. J Med Sci Clin Res. 2017;5(11). doi:10.18535/jmscr/v5i11.217

Qureshi AR, Irfan M, Ashraf Z. Diagnostic accuracy of combined sonographic findings and pleural fluid adenosine deaminase levels for tuberculous pleural effusions in endemic areas-A study of 415 patients. J Fatima Jinnah Med Univ. 2019;13(1):18-22.

Pandit S, Chaudhuri AD, Datta SBS, Dey A, Bhanja P. Role of pleural biopsy in etiological diagnosis of pleural effusion. Lung India Off organ Indian Chest Soc. 2010;27(4):202.

Karkhanis VS, Joshi JM. Pleural effusion: diagnosis, treatment, and management. Open access Emerg Med OAEM. 2012;4:31.

Soe Z, Shwe WH, Moe S. A study on tuberculous pleural effusion. Int J Collab Res Intern Med Public Heal. 2010;2(3):31.

Ezung T, Devi NT, Singh NT, Singh TB. Pulmonary tuberculosis and diabetes mellitus--a study. J Indian Med Assoc. 2002;100(6):376-378.

Ferreiro L, Toubes ME, Valdés L. Contribution of pleural fluid analysis to the diagnosis of pleural effusion. Med Clínica (English Ed. 2015;145(4):171-177.

Burgess LJ, Maritz FJ, Le Roux I, Taljaard JJF. Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio: increased specificity for the diagnosis of tuberculous pleuritis. Chest. 1996;109(2):414-419.

Popowicz N, Cheah HM, Gregory C, et al. Neutrophil-to-lymphocyte ratio in malignant pleural fluid: Prognostic significance. PLoS One. 2021;16(4):e0250628.

Srinidhi R, Mathangi K, Kumar KR. Role of ADA and CBNAAT (Cartridge Based Nucleic Acid Amplification Test) in diagnosis of Tuberculosis in straw coloured exudative pleural effusion in patients attending Government General Hospital, KAKINADA. tuberculosis. 2020;4:5.

Chakraborty A, Ramaswamy S, Shivananjiah AJ, Chikkavenkatappa N. The role of genexpert in the diagnosis of tubercular pleural effusion in India. Adv Respir Med. 2019;87(5):276-280.

Downloads

Published

2024-07-04

Issue

Vol. 15 No. 3 (2024): Indian Journal of Public Health and Research Development

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Association of Cytological and Biochemical Parameters with Pleural Effusion in Patients Attending a Tertiary Care Hospital of Western U.P. (2024). Indian Journal of Public Health Research & Development, 15(3), 234-238. https://doi.org/10.37506/6nkafs72