Diagnostic utility of bone marrow examination in pancytopenia cases in tertiary care centre
DOI:
https://doi.org/10.37506/02vq0b89Keywords:
Bone Marrow Examination , Hypoplastic Marrow , Megaloblastic Anaemia, PancytopeniaAbstract
Background & objectives : Pancytopenia may be a manifestation of wide variety of disorders which primarily or secondarily affects the bone marrow. Bone marrow aspiration is a minimally invasive , out – patient procedure which provides definitive diagnosis in cases of pancytopenia. The present study was conducted to analyse the various causes of pancytopenia by evaluating bone marrow aspiration and to correlate bone marrow aspiration findings with clinical presentation, complete blood counts and peripheral blood picture. Methods : This prospective study was conducted in the Department of Pathology , Muzaffarnagar Medical College for a period of 12 months . Total 60 cases were evaluated for pancytopenia. Results : Out of 60 cases, 25 (41.7%) cases were females and 35 (58.3%) were males with slight male preponderance . Maximum number of cases were in the age group of 31 - 40 years. Most common cause of pancytopenia was megaloblastic anaemia followed by hypoplastic marrow , iron deficiency anaemia , nutritional deficiency and others. Interpretation & Conclusion: Along with detailed clinical examination and complete blood count , bone marrow examination is still the indispensable diagnostic modality to diagnose the aetiology of pancytopenia.
References
Examination of blood and bone marrow. John P. Greer, Daniel A. Arber In: Sherrie L. Perkins editors. Wintrobe Clinical Haematology. 10th edition , Maryland: Williams and Wilkins; 1999; 23- 32.
Williams M.D. Pancytopenia, aplastic anemia and pure red cell aplasia. G.Richard Lee, John P. Greer, George M. Rodgers, editors. Wintrobe’s clinical Haematology, 10th edition, Lippincott Williams and Wilkins A Wolters Kluwer Company. 1993; 1449-84.
Weinzierl EP, Arber DA. The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia. Am J Clin Pathol. 2013; 139(1):9-29.
Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia – a clinicohaematological study of 200 cases. Indian J PatholMicrobiol. 2002; 45(3): 375-79.
Ojha S, Haritwal A, Meenai FJ, Gupta S. Bone marrow examination findings in cases of pancytopenia-a study from central India. Indian Journal of Pathology and Oncology. 2016 Jul;3(3):479-84.
Tilak V, Jain R. Pancytopenia-a clinico-hematologic analysis of 77 cases. Indian J PatholMicrobiol. 1999; 42(4):399-404
Kumar V , Khare M , Kishore M , Sharma M , Marwah S, Nigam AS ,et al . Diagnostic Approach of New – Onset Pancytopenia : Study from a Tertiary Care Center Pancytopenia . Ann Pathol Lab Med. 2018 ; 5(8):A641 -6
Marwah N, Bhutani N, Singh S, Kalra R, Gupta M, Sen R. The spectrum of haematological disorders from bone marrow aspiration cytology in a tertiary care centre. 2017; 9(1):44938-41.
Chandan R.H, Giriyan S.S. Role of bone marrow aspiration and biopsy in elaborating the diagnosis of pancytopenia. Trop J Path Micro 2018;4(2):144-149
Khodke K, Marwah S, Buxi G, Vadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Academy Clin Med 2001;2:55-9
Gayathri BN, Rao KS.Pancytopenia:a clinic hematological study. J Lab Physicians. 2011 Jan;3(1):15-20
Yadav S , Kushwaha R , Journal of Evolution of Medical and Dental Sciences.2013 June 3;2(22):4013-23
Makheja KD, Maheshwari BK, Arain S, Kumar S, Kumari S, Vikash. The common causes leading to pancytopenia in patients presenting to tertiary care hospital. Pak J Med Sci. 2013;29(5):1108-1111
Patel G R, Prajapati G R . Spectrum of Pancytopenia in Adults Attending a Clinical Hematology Department: A Four-Year Experience From a Tertiary Care Center of Western India. Cureus 2022 May 12;14(5): e24933.
Agrawal P, Singh Y, Agrawal N. Haematological evaluation in patients of pancytopenia by bone marrow aspiration. J Evolution Med Dent Sci 2021;10(19):1398- 1402
Marwah N , Bhutani N ,Singh S , Kalra R , Gupta M , Sen R . The spectrum of haematological disorders from bone marrow aspiration cytology in a tertiary care centre. 2017;9(1):44938-41
Prakash A , Nerune SN,Badiger S , Gupta S , International Journal of Academic Medicine and Pharmacy (www.academicmed.org) ISSN (O): 2687-5365; ISSN (P): 2753-6556
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone marrow examination in cases of pancytopenia. JNMA J Nepal Med Assoc. 2008 Jan-Mar;47(169):12-7.
Khare M , Singh P , Diagnostic Approach of New-Onset Pancytopenia: Study from A Tertiary Care Center Pancytopenia 2 Years Retrospective Study. Annals of Pathology and Laboratory Medicine; 2018 Aug 5(8):A 641-46
Shah R, Patel K. Evaluation of bone marrow in patients with pancytopenia. Panacea J Med Sci 2020;10(3):209-215
DesalphineM , To evaluate the role of Bone Marrow Aspiration and Bone Marrow Biopsy in Pancytopenia. Journal of Clinical and Diagnostic Research. 2014 Nov;8(11): FC11-FC15
Zhang J et al. In situ mapping identifies distinct vascular niches for myelopoiesis. Nature. 2021 Feb 10;590(7846):457-462.
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