Effects of Topical No Toner and Essence on Skin Changes in the Subjects with Acne Vulgaris

Abstract

Background: Acne vulgaris (AV) is a very common condition with an estimated lifetime prevalence of
85% and occurs predominantly during adolescence. The aim of current study was to investigate how the
NO-containing essences and toners change the skin condition of AV patients using nitric oxide (NO) with
these various positive effects.
Method: The experiment proceded with 25 subjects in the acne skin experimental group with NO essence
and toner (AE), 25 subjects in the normal skin experimental group with NO essence and toner (NE), and
20 subjects in the normal skin control group without any application of the products (NC). Skin analyzer
(Mark-Vu, Korea) was used to examine the skin changes.
Results: The changes in pores, sebum, inflammation, wrinkles, flush, skin tone, radiance brightness, and
radiance area before and after the experiment between three groups were statistically significant decreased
and melanin increased in both AE and NE. A statistically significant change was only seen in AE (p< 0.05).
There was a statistically significant decrease in NE and a statistically significant decrease in brown was
only seen in NE (p< 0.05). After 8 weeks, Pore size and future wrinkles were significantly reduced in
AE compared to the other groups (p <0.05). There was a statistically significant difference in pore sizes,
future wrinkles in AE and NC in the post-test using the Sheffe test (p <0.05). After the experiment, sebum,
inflammation, wrinkle decreased in AE and NE, but there was no statistically significant decrease between
the three groups.
Conclusion: Essences and toners containing NO were found to be effective in improving AV and normal
skin.