Changes in Blood Serum Levels of IGFI in Type 2 Diabetes and Alzheimer’s Disease in Saudi Population: An Observational Study

Authors

  • Fatimah Abdou Khormi1, Safa Yousef Qusti2, Madiha Noah Sini3

DOI:

https://doi.org/10.37506/ijphrd.v11i3.2221

Keywords:

Type 2 diabetes, Alzheimer’s disease, IGF1,insulin, Saudi Arabia.

Abstract

Context: The prevalence of Alzheimer’s disease (AD) in the Middle East including Saudi Arabia is increasing
rapidly, heightening the importance of finding effective preventive therapies and identifying the possibility
risk factors such as Type 2 Diabetes (T2DM). Over the lastfew years is has been suggested that T2DM
and AD are linked. Many researchers suggested insulin growth factor (IGF1) and insulin signaling could
be the relation between the two pathologies. To gain insights onthis relation, an observational study was
initiated. We recruited and interviewed 300 research participants (age ? 65 years): 100 controls, 100 T2DM
and 100 AD. We assessed the association between glycated hemoglobin (HbA1c) and MiniMental State
Examination(MMSE) with IGF1 for all groups. No Significant differences between groups were observed
for age and body mass index (BMI) (p < 0.0001).AD patients have significant decrease in MMSE among
other groups.T2DM group had the highest level of HbA1c% (7.83) among other groups. The highest level
of IGF1 were found in control group. MMSE score was negatively related with HbA1c% while positively
correlated with IGF1. Negative relation was found between HbA1c score and IGF1. These results suggest
that blood serum levels of IGF1 decreased in patients with T2DM and AD and this may be the shared cellular
and molecular connections between T2DM and AD in Saudi population. AD was associated with poor
glycemic control, blood serum levels of IGF1. Further investigation into this area may unravel important
clues to the nature of this diseases to improve public health worldwide.

Author Biography

  • Fatimah Abdou Khormi1, Safa Yousef Qusti2, Madiha Noah Sini3

    1Assistant Professor of Biochemistry,2, 3Professor of Biochemistry, Faculty of Science,
    King Abdulaziz University, Jeddah, Saudi Arabia

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Published

2020-03-26

How to Cite

Changes in Blood Serum Levels of IGFI in Type 2 Diabetes and Alzheimer’s Disease in Saudi Population: An Observational Study. (2020). Indian Journal of Public Health Research & Development, 11(3), 1957-1961. https://doi.org/10.37506/ijphrd.v11i3.2221