Lifestyle choices influence the susceptibility towards Essential Hypertension.
DOI:
https://doi.org/10.37506/fmm0jk93Keywords:
Hypertension, lifestyle, biochemical parameters, blood pressureAbstract
Background: Despite provisions of anti-hypertensives and WHO measures, prevalence of hypertension is increasing worldwide, especially in low-& middle-income countries. This indicates a common issue, probably non-affordability of medicines and non-availability of proper health care facilities to larger section of population. This provided two important objectives to the study, first to investigate the basic health parameters of hypertensive and normotensive individuals and second to correlate their lifestyle choices with health parameters to understand the cause and effect.
Methods: The cross-sectional study was conducted through the consecutive recruitment of hypertensive and normotensive individuals between January 2024 to September 2024 at Advanced Cardiac Centre, PGIMER. Data regarding participants lifestyle habits and biochemical parameters were collected using case record forms. Statistical analysis, including intergroup and intragroup comparisons, was performed using Chi-square test, unpaired t-test (Mann-Whitney test), descriptive analysis. A p-value <0.05 was considered statistically significant. Additionally, logistic regression analysis was conducted to evaluate the association between biochemical parameters and hypertension as predictive variables.
Results: A higher proportion of individuals with a sedentary lifestyle were observed in the hypertensive group. Further analysis of normotensive individuals with sedentary lifestyles revealed that 78.5% were vegetarians and only a small fraction reported with alcohol consumption. In contrast, hypertensives with a sedentary habits exhibited higher rates of non-vegetarian food intake (76.2%) and alcohol consumption (71.4%).
Conclusion: This study underscores lifestyle modifications as the primary strategy to improve the overall health parameters, to reduce the increasing prevalence of hypertension, as well as reduce drug dependence.
References
Ozyuncu N, Erol C. How can we increase the efficacy of antihypertensive treatment?. Polish Heart Journal (Kardiologia Polska). 2024;82(1):19-28.
https://journals.viamedica.pl/polish_heart_journal/article/view/98705
Wu Y, Li L, Zhou J, Zhang J, Wang Y, Yu L, Liu T. Impact of blood pressure control level on all-cause mortality and CVD mortality in patients with hypertension and its comorbidities: A prospective cohort study in Southwest China. medRxiv. 2024; 31:2024-05.
https://www.medrxiv.org/content/10.1101/2024.05.30.24308250v1
Ma J, Chen X. Advances in pathogenesis and treatment of essential hypertension. Frontiers in cardiovascular medicine. 2022; 9:1003852.
https://www.frontiersin.org/journals/cardiovascularmedicine/articles/10.3389/fcvm.2022.1003852/full
Flack JM, Adekola B. Blood pressure and the new ACC/AHA hypertension guidelines. Trends in cardiovascular medicine. 2020;30(3):160-4.
https://www.sciencedirect.com/science/article/pii/S1050173819300684
Bakris G, Ali W, Parati G. ACC/AHA versus ESC/ESH on hypertension guidelines: JACC guideline comparison. Journal of the American College of Cardiology. 2019;73(23):3018-26.
https://www.jacc.org/doi/abs/10.1016/j.jacc.2019.03.507
Rebholz CM, Crews DC, Grams ME, Steffen LM, Levey AS, Miller III ER, Appel LJ, Coresh J. DASH (Dietary Approaches to Stop Hypertension) diet and risk of subsequent kidney disease. American Journal of Kidney Diseases. 2016;68(6):853-61.
https://www.sciencedirect.com/science/article/pii/S0272638616302578
Moore TJ, Conlin PR, Ard J, Svetkey LP, DASH Collaborative Research Group. DASH (Dietary Approaches to Stop Hypertension) diet is effective treatment for stage 1 isolated systolic hypertension. Hypertension. 2001;38(2):155-8.
https://www.ahajournals.org/doi/full/10.1161/01.HYP.38.2.155
Liu X, Zhang D, Liu Y, Sun X, Han C, Wang B. Dose–response association between physical activity and incident hypertension: a systematic review and meta-analysis of cohort studies. J Hypertens. 2017;69(5):813-20.
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.116.08994
Groppelli A, Giorgi DM, Omboni S, Parati G, Mancia G. Persistent blood pressure increase induced by heavy smoking. J hypertens. 1992;10(5):495-9.
https://pubmed.ncbi.nlm.nih.gov/1317911/
Seyedzadeh A, Hashemi F, Soleimani A. Relationship between blood pressure and passive smoking in elementary school children. Iranian Journal of Pediatrics. 2012;22(3):351.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3564091/
Talukder MH, Johnson WM, Varadharaj S, Lian J, Kearns PN, El-Mahdy MA, Liu X, Zweier JL. Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice. American Journal of Physiology-Heart and Circulatory Physiology. 2011;300(1):H388-96.
https://journals.physiology.org/doi/full/10.1152/ajpheart.00868.2010
Tuomilehto J, Elo J, Nissinen A. Smoking among patients with malignant hypertension. British Medical Journal (Clinical research ed.). 1982;284(6322):1086.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1497930/
Landi F, Calvani R, Picca A, Tosato M, Martone AM, Ortolani E, Sisto A, D’Angelo E, Serafini E, Desideri G, Fuga MT. Body mass index is strongly associated with hypertension: Results from the longevity check-up 7+ study. Nutrients. 2018;10(12):1976.
https://www.mdpi.com/2072-6643/10/12/1976
Shuger SL, Sui X, Church TS, Meriwether RA, Blair SN. Body mass index as a predictor of hypertension incidence among initially healthy normotensive women. American Journal of Hypertension. 2008;21(6):613-9.
https://academic.oup.com/ajh/article/21/6/613/169505
Seravalle G, Grassi G. Obesity and hypertension. Obesity: clinical, surgical and practical guide. 2024; 31:65-79.
https://link.springer.com/chapter/10.1007/978-3-031-62491-9_5
Verma A, Patel P, Patel JR, Chaudhary H. Relation of BMI & hypertension in natives of Gujarat. GCSMC J Med Sci. 2013;2(1):17-20.
https://www.gcsmc.org/assets/pdf/journal/vol2num1jan2013201810061105002617400.pdf#page=19
Chen M, Liu J, Fan M, Li B, Ren Y, Xu S. Association of alcohol consumption with hypertension or prehypertension in Chinese adolescent: A cohort study of the China Health and Nutrition Survey. The Journal of Clinical Hypertension. 2024;26(11):1228-36.
https://onlinelibrary.wiley.com/doi/full/10.1111/jch.14895
Potter JF, Beevers DG. Pressor effect of alcohol in hypertension. The Lancet. 1984 ;323(8369):119-22.
https://www.sciencedirect.com/science/article/abs/pii/S0140673684900606
Son MK. Association between alcohol consumption and hypertension. J Korean Soc Hypertens. 2011;17(2):65-73.
Klatsky AL. Alcohol-associated hypertension: when one drinks makes a difference. Hypertension. 2004;44(6):805-6.
https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000146538.26193.60
Markel AL, Redina OE, Gilinsky MA, Dymshits GM, Kalashnikova EV, Khvorostova YV, Fedoseeva LA, Jacobson GS. Neuroendocrine profiling in inherited stress-induced arterial hypertension rat strain with stress-sensitive arterial hypertension. Journal of Endocrinology. 2007;195(3):439-50.
Conversano C, Orrù G, Pozza A, Miccoli M, Ciacchini R, Marchi L, Gemignani A. Is mindfulness-based stress reduction effective for people with hypertension? A systematic review and meta-analysis of 30 years of evidence. International journal of environmental research and public health. 2021;18(6):2882.
https://www.mdpi.com/1660-4601/18/6/2882
Darviri C, Artemiadis AK, Protogerou A, Soldatos P, Kranioutou C, Vasdekis S, Varvogli L, Nasothimiou E, Vasilopoulou E, Karantzi E, Linardatou A. A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for prehypertensive and hypertensive patients: a quasi-experimental study in Greece. Journal of Human Hypertension. 2016;30(6):397-403.
https://www.nature.com/articles/jhh201599
Hapsari VA, Nasruddin H, Pancawati E. Relationship Between Lifestyle And Hypertension Incidence. Jurnal EduHealth. 2024;15(04):1318-25.
https://ejournal.seaninstitute.or.id/index.php/healt/article/view/6041
Drury ER, Wu J, Gigliotti JC, Le TH. Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms. Physiological Reviews. 2024;104(1):199-251.
https://journals.physiology.org/doi/full/10.1152/physrev.00041.2022
Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biology of sex differences. 2017;8(1):33.
https://link.springer.com/article/10.1186/s13293-017-0152-8
Aryan L, Younessi D, Zargari M, Banerjee S, Agopian J, Rahman S, Borna R, Ruffenach G, Umar S, Eghbali M. The role of estrogen receptors in cardiovascular disease. International journal of molecular sciences. 2020;21(12):4314.
https://www.mdpi.com/1422-0067/21/12/4314
Soltani Z, Washco V, Morse S, Reisin E. The impacts of obesity on the cardiovascular and renal systems: cascade of events and therapeutic approaches. Current hypertension reports. 2015 ;17(2):7.
https://link.springer.com/article/10.1007/s11906-014-0520-2
Bricarello LP, Poltronieri F, Fernandes R, Retondario A, de Moraes Trindade EB, de Vasconcelos FD. Effects of the Dietary Approach to Stop Hypertension (DASH) diet on blood pressure, overweight and obesity in adolescents: A systematic review. Clinical nutrition ESPEN. 2018; 28:1-1.
https://www.sciencedirect.com/science/article/pii/S2405457718304571
Filippou CD, Tsioufis CP, Thomopoulos CG, Mihas CC, Dimitriadis KS, Sotiropoulou LI, Chrysochoou CA, Nihoyannopoulos PI, Tousoulis DM. Dietary approaches to stop hypertension (DASH) diet and blood pressure reduction in adults with and without hypertension: a systematic review and meta-analysis of randomized controlled trials. Advances in nutrition. 2020 1;11(5):1150-60.
https://www.sciencedirect.com/science/article/pii/S2161831322000473
Craddick SR, Elmer PJ, Obarzanek E, Vollmer WM, Svetkey LP, Swain MC. The DASH diet and blood pressure. Current atherosclerosis reports. 2003;5(6):484-91.
https://link.springer.com/article/10.1007/s11883-003-0039-5
Ranasinghe P, Cooray DN, Jayawardena R, Katulanda P. The influence of family history of hypertension on disease prevalence and associated metabolic risk factors among Sri Lankan adults. BMC public health. 2015;15(1):576.
https://link.springer.com/article/10.1186/s12889-015-1927-7
Zhong X, Hilton HJ, Gates GJ, Jelic S, Stern Y, Bartels MN, DeMeersman RE, Basner RC. Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. Journal of applied physiology. 2005;98(6):2024-32.
https://journals.physiology.org/doi/full/10.1152/japplphysiol.00620.2004
Bourdillon N, Jeanneret F, Nilchian M, Albertoni P, Ha P, Millet GP. Sleep deprivation deteriorates heart rate variability and photoplethysmography. Frontiers in neuroscience. 2021; 15:642548.
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.642548/full
Dettoni JL, Consolim-Colombo FM, Drager LF, Rubira MC, Cavasin de Souza SB, Irigoyen MC, Mostarda C, Borile S, Krieger EM, Moreno Jr H, Lorenzi-Filho G. Cardiovascular effects of partial sleep deprivation in healthy volunteers. Journal of applied physiology. 2012;113(2):232-6.
https://journals.physiology.org/doi/full/10.1152/japplphysiol.01604.2011
Chen S, Cheng W. Relationship between lipid profiles and hypertension: a cross-sectional study of 62,957 Chinese adult males. Frontiers in public health. 2022;10:895499.
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.895499/full
Carvalho LS, Panzoldo N, Santos SN, Modolo R, Almeida B, e Silva JC, Nadruz-Jr W, de Faria EC, Sposito AC, Brasilia Heart Study Group. HDL levels and oxidizability during myocardial infarction are associated with reduced endothelial-mediated vasodilation and nitric oxide bioavailability. Atherosclerosis. 2014;237(2):840-6.
https://www.sciencedirect.com/science/article/pii/S0021915014015585
Cachofeiro V, Miana M, Martín-Fernandez B, Ballesteros S, Balfagon G, Lahera V. Inflammation: a link between hypertension and atherosclerosis. Current Hypertension Reviews. 2009;5(1):40-8.
Hage FG. C-reactive protein and hypertension. Journal of human hypertension. 2014;28(7):410-5.
https://www.nature.com/articles/jhh2013111
Valenzuela PL, Carrera-Bastos P, Gálvez BG, Ruiz-Hurtado G, Ordovas JM, Ruilope LM, Lucia A. Lifestyle interventions for the prevention and treatment of hypertension. Nature Reviews Cardiology. 2021;18(4):251-75.
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