The Correlation Between Nesfatin-1 Level and Insulin Resistance in Gestational Diabetes Verses Control

Abstract

Objective: The examination of nesfatin-1 level in females with gestational diabetes versus controls and its
relation with the markers of insulin resistance.
Method: The study was accomplished for eighty eight pregnant females at 24th -28th week of gestation
which were involved 44 females diagnosed with gestational diabetes and 44 females without. Age and
bone mass index were matched in two groups. Nesfatin-1 and insulin concentrations were measured by
using enzyme linked immunosorbent assay. Insulin level and (homeostasis model assessment index- insulin
resistance) were measured in two groups. The manufacture instructions were performed accurately. The
comparison between previous parameters was performed.
Results: The level of nesfatin-1 wasn´t differed significantly between two groups. While insulin, homeostasis
model assessment index-insulin resistance and fasting blood glucose were significantly increased in
gestational diabetes than control groups.
Conclusion: The mean of nesfatin-1 levels showed no significant difference between two groups. While
fasting blood glucose, insulin, and homeostasis model assessment index-insulin resistance were significantly
higher in GDM. Advance age, higher bone mass index were associated of gestational diabetes.