Association between CTG Parameters One Hour before Delivery and Neonatal Asphyxia
DOI:
https://doi.org/10.37506/r90vh961Abstract
Background: Cardiotocography (CTG) is a vital tool in obstetric practice for real-time fetal monitoring. However, its predictive value in identifying neonatal asphyxia remains underexplored, particularly in the critical hour before delivery.
Aim of the Study: This study investigates the association between CTG monitoring in the last hour before delivery and neonatal asphyxia, aiming to evaluate its predictive value.
Patients and Methods:This study is a descriptive retrospectivecohort study conducted at Al-Elwiya Maternity Teaching Hospital between January 2024 and January 2025. The study included 250 pregnant women presented with labourcondition to the mentionedhospital, CTG monitoring was applied continuously. After delivery (whether by vaginal delivery or caesarean section)CTG of last hour before delivery was compared for the neonates who had asphyxia and those without asphyxia. Inclusion criteria were: Term months, no history of taking drug, before delivery that affects the heart rate of the foetus (as magnesium sulphate, narcotics and pain killers), no history of fever, no history of drugs, addition, not smoker, not alcoholic, babies without congenital anomalies. Exclusion criteria: Preterms, mothers with medical disease like diabetes mellitus and hypertension,addiction to smoking and alcohol, mothers taking drugs that affect the heart rate of the focus like (magnesium sulphate, narcotics and pain killers, maternal fever, neonates with congenital anomaly, extremes of reproductive age group and extremes of BMI (<18.5 or ≥ 25 kg/m2).
Results: Pathological CTG patterns were observed in 70% of the asphyxia group, compared to 1.6% in the non-asphyxia group. Late decelerations, absent variability, and accelerations were significantly associated with asphyxia. Caesarean delivery was more common in the asphyxia group. The need of NICU admissions further emphasized the poor neonatal outcomes.
Conclusion: CTG monitoring in the last hour before delivery shows significant predictive potential for neonatal asphyxia. Specific CTG patterns can guide timely obstetric interventions, which can lead to improve neonatal outcomes.
References
Ayres-de-Campos D, Spong CY, Chandraharan E. FIGO consensus guidelines on intrapartum fetal monitoring: Cardiotocography. International Journal of Gynecology & Obstetrics. 2015;131(1):13-24.
Kamala BA, Kidanto HL, Wangwe PJ, Dalen I, Mduma ER, Perlman JM, et al. Intrapartum fetal heart rate monitoring using a handheld Doppler versus Pinard stethoscope: a randomized controlled study in Dar es Salaam. Int J Womens Health. 2018;10:341-8.
Clark SL, Nageotte MP, Garite TJ, Freeman RK, Miller DA, Simpson KR, et al. Intrapartum management of category II fetal heart rate tracings: towards standardization of care. American journal of obstetrics and gynecology. 2013;209(2):89-97.
Kasahara Y, Yoshida C, Saito M, Kimura Y. Assessments of heart rate and sympathetic and parasympathetic nervous activities of normal mouse fetuses at different stages of fetal development using fetal electrocardiography. Frontiers in Physiology. 2021;12:652828.
Jongen G. Simulation of the cardiotocogram during labor: towards model-based understanding of fetal physiology. 2016.
Ndjapa-Ndamkou C, Govender L, Bhoora S, Chauke L. The role of the placenta in perinatal asphyxia, neonatal encephalopathy, and neurodevelopmental outcome: A review. African Journal of Reproductive Health. 2023;27(1):107-18.
Odd D, Heep A, Luyt K, Draycott T. Hypoxic-ischemic brain injury: Planned delivery before intrapartum events. J Neonatal Perinatal Med. 2017;10(4):347-53.
Kapaya H, Williams R, Elton G, Anumba D. Can Obstetric Risk Factors Predict Fetal Acidaemia at Birth? A Retrospective Case-Control Study. J Pregnancy. 2018;2018:2195965.
Viaroli F, Cheung PY, O'Reilly M, Polglase GR, Pichler G, Schmölzer GM. Reducing Brain Injury of Preterm Infants in the Delivery Room. Front Pediatr. 2018;6:290.
Pereira S, Chandraharan E. Recognition of chronic hypoxia and pre-existing foetal injury on the cardiotocograph (CTG): Urgent need to think beyond the guidelines. Porto biomedical journal. 2017;2(4):124-9.
Chandraharan E. Updated NICE Cardiotocograph (CTG) guideline: Is it suspicious or pathological. J Clin Med Surgery. 2023;3(2):1129.
Alfirevic Z, Devane D, Gyte GM, Cuthbert A. Continuous cardiotocography (CTG) as a form of electronic fetal monitoring (EFM) for fetal assessment during labour. Cochrane Database Syst Rev. 2017;2(2):Cd006066.
Hamilton E, Warrick P, O’Keeffe D. Variable decelerations: do size and shape matter? The Journal of Maternal-Fetal & Neonatal Medicine. 2012;25(6):648-53.
Farquhar CM, Armstrong S, Masson V, Thompson JMD, Sadler L. Clinician Identification of Birth Asphyxia Using Intrapartum Cardiotocography Among Neonates With and Without Encephalopathy in New Zealand. JAMA Network Open. 2020;3(2):e1921363-e.
Cahill AG, Tuuli MG, Stout MJ, López JD, GA. M. A prospective cohort study of fetal heart rate monitoring: deceleration area is predictive of fetal acidemia. . American journal of obstetrics and gynecology. 2018;218(5):523.
Shaffer F, Ginsberg J. An overview of heart rate variability metrics and norms. Front Public Health. 2017; 5: 258.
Ukoha EP, Wen T, Reddy UM. Induction of labor vs expectant management among low-risk patients with 1 prior cesarean delivery. American Journal of Obstetrics & Gynecology.
Christiansen S, Nwankwo C. Fetal heart accelerations and decelerations. Very Well Health, 2024.
Abbasalizadeh F, Abbasalizadeh S, Pouraliakbar S, Bastani P. Correlation between nonreassuring patterns in fetal cardiotocography and birth asphyxia. 2015.
Getaneh FB, Sebsbie G, Adimasu M, Misganaw NM, Jember DA, Mihretie DB, et al. Survival and predictors of asphyxia among neonates admitted in neonatal intensive care units of public hospitals of Addis Ababa, Ethiopia, 2021: a retrospective follow-up study. BMC pediatrics. 2022;22(1):262.
Aslam HM, Saleem S, Afzal R, Iqbal U, Saleem SM, Shaikh MWA, et al. Risk factors of birth asphyxia. Italian Journal of Pediatrics. 2014;40(1):94.
Nauman Kiyani A, Khushdil A, Ehsan A. Perinatal Factors Leading to Birth Asphyxia among Term Newborns in a Tertiary Care Hospital. Iran J Pediatr. 2014;24(5):637-42.
Gizachew S, Wogie G, Getnet M, Lonsako AA. Magnitude of neonatal asphyxia and its predictors among newborns at public hospitals of Wolaita Zone in Southern Ethiopia, 2023. BMC Pediatrics. 2024;24(1):142.
Techane MA, Alemu TG, Wubneh CA, Belay GM, Tamir TT, Muhye AB, et al. The effect of gestational age, low birth weight and parity on birth asphyxia among neonates in sub-Saharan Africa: systematic review and meta-analysis: 2021. Italian Journal of Pediatrics. 2022;48(1):114.
Mitha A, Chen R, Johansson S, Razaz N, Cnattingius S. Maternal body mass index in early pregnancy and severe asphyxia-related complications in preterm infants. International Journal of Epidemiology. 2020;49(5):1647-60.
Ahmed R, Mosa H, Sultan M, Helill SE, Assefa B, Abdu M, et al. Prevalence and risk factors associated with birth asphyxia among neonates delivered in Ethiopia: A systematic review and meta-analysis. PloS one. 2021;16(8):e0255488.
Tegegnework SS, Gebre YT, Ahmed SM, Tewachew AS. Determinants of birth asphyxia among newborns in Debre Berhan referral hospital, Debre Berhan, Ethiopia: a case-control study. BMC Pediatrics. 2022;22(1):165.
Sawangkum PS, Salemi JL, Tanner JPP, Kaimal AJ. 586 Association of Mode of Delivery for Periviable Birth with Neonatal Outcomes. American Journal of Obstetrics & Gynecology. 2024;230(1):S317.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.