Relationship between Serum Uric Acid and Lipid Profiles in Thai Adults

Abstract

Although the link between serum uric acid, including hyperuricemia and metabolic syndrome had been
reported, the relationship of lipid profiles with serum uric acid remains not comprehensively assessed in
Thai adults. This current study was performed to examine the relation between serum uric acid and lipid
profiles in Thai adults. A total of 192 blood samples were collected from Thai adults aged 20 years and over
(men, n = 67 and women, n = 125). We analyzed serum uric acid levels and serum lipid profiles, including
serum total cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein. Multiple linear
regression analysis was used to evaluate the relationship between serum uric acid and lipid profiles. Our
results found that triglycerides and total cholesterol was linearly related with serum uric acid levels (0.404,
95% CI, 0.578, 95% CI 0.164-0.993, respectively). Meanwhile an inverse relation was observed between
serum uric acid levels and high-density lipoprotein (-0.042, 95% CI -0.015 - -0.067).
This study suggested that triglycerides, total cholesterol and obesity had a significant linear association with
serum uric acid levels, whereas serum HDL cholesterol levels are significantly inversely associated.The
early prevention of obesity and dyslipidemia can reduce the incidence of associated hyperuricemia and gout
among Thai adults