The Combination of SLC2A9 Gene (rs2280205 and rs6820230) and Major Metabolic Factors with Association to Gout in Thai Men; A Matched Case-Control Study

Authors

  • Kitsarawut Khuancharee1, Chantra Tanunyutthawongse2, Pongdech Sarakarn3

DOI:

https://doi.org/10.37506/ijphrd.v11i3.2863

Keywords:

rs2280205 variant, rs6820230 variant, gout, metabolic parameters

Abstract

A combination of non-synonymous variants, rs2280205 and rs6820230 of the SLC2A9 gene and major
metabolic parameters contribute to developing gout remains not well studied or assessed in Thai men. This
study was conducted to assess the association between combined of two non-synonymous variants and
gout. Using data from male subjects of age ? 20 years in the Genetic variation of Urate transporter genes
in Hyperuricemia and Gout among Thai population Study (GUHGTHS). We randomly performed a 1:1
age-matched case-control study that included 48 gout patients and 48 non-gout subjects. Using multivariate
logistic regression analysis was used to analyze data. The single and joint locus effect of rs2280205 and
rs6820230 variants were independently associated with gout. However, the combination of rs2280205 and
high fasting glucose, including rs6820230 variant and high fasting glucose were associated with gout, the
adjusted odds ratio was 13.70-fold and 5.81-fold, respectively. Meanwhile, we did not observe an association
between these variants and high blood pressure, including general obesity with gout.
In conclusion, rs2280205 and rs6820230 variants did independently associated with increased risk of gout,
but predominantly occurred in high fasting glucose subjects. However, further studies with larger sample
sizes and homogeneous populations should be confirmed these results.

Author Biography

  • Kitsarawut Khuancharee1, Chantra Tanunyutthawongse2, Pongdech Sarakarn3

    1Doctor of Philosophy Program candidate, Department of Epidemiology and Biostatistics, Faculty of Public
    Health, Khon Kaen University, Khon Kaen 40002, Thailand, 2 Department of Biochemistry, Faculty of Medicine,
    Srinakharinwirot University, Bangkok 10110, Thailand, 3ASEAN Cancer Epidemiology and Prevention Research
    Group (ACEP), Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University,
    Khon Kaen 40002, Thailand

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Published

2020-03-26

How to Cite

The Combination of SLC2A9 Gene (rs2280205 and rs6820230) and Major Metabolic Factors with Association to Gout in Thai Men; A Matched Case-Control Study. (2020). Indian Journal of Public Health Research & Development, 11(3), 2436-2441. https://doi.org/10.37506/ijphrd.v11i3.2863