Autonomic Function Tests in Chronic Obstructive Pulmonary Disease (COPD) and their Correlation with Disease Severity

Authors

  • Ganesan R.1, Gaur G.S.2, Karthik S.3, Vishnukanth4

DOI:

https://doi.org/10.37506/ijphrd.v11i3.702

Keywords:

Autonomic function tests, COPD, Cardiovascular risk, FEV1, GOLD criteria

Abstract

Background: Chronic hypoxemia in COPD patients, predispose them to cardiovascular autonomic
neuropathy and cause sudden cardiorespiratory arrest. COPD patients without hypoxemia can also develop
cardiovascular autonomic neuropathy. Similarly, cardiovascular autonomic neuropathy, though observed
more often in patients with moderate and severe COPD, can also occur in patients with mild COPD. There
is paucity of literature, revealing the relationship of autonomic function tests with disease severity in COPD
patients.
Objective: In our study we intended to assess, autonomic function tests among different stages of COPD
and also to identify the association of these autonomic function tests with disease severity.
Method: It is a Cosssectional studydone on (n=130) male COPD patients (who could maintain oxygen
saturation above 88%). Anthropometric parameters, autonomic function tests and Pulmonary function test
were assessed. Later, based on the GOLD stage criteria they were divided into 4 sub-groups. Data were
analysed by SPSS 19.0 version software. One-way ANOVA was used to find Statistical difference between
the groups. Correlations between the variables were done using Pearson correlation test.
Results: 30/15 ratio and E/I ratio levels were significantly decreased in very severe, severe and moderate
COPD patients when compared to mild COPD patients. The ?DBPIHG levels were significantly increased
during isometric handgrip in very severe, severe and moderate COPD patients when compared to mild
COPD patients. E/I ratio (r=-0.463), 30/15 ratio (r=-0.496) negatively correlated with disease severity and
?DBPIHG levels (r=0.687) positively correlated with disease severity
Conclusion: In our study group of COPD patients, we found increase in the sympathetic vascular BP
response which gets increased as the disease severity is increased.30/15 ratio and E/I ratio levels negatively
correlated with disease severity and ?DBPIHG levels positively correlated with disease severity.

Author Biography

  • Ganesan R.1, Gaur G.S.2, Karthik S.3, Vishnukanth4

    1Assistant Professor, Department of Physiology, MelmaruvathurAdhiparasakthi Institute of Medical Sciences
    and Research, Melmaruvathur, Tamil nadu, India, 2Professor, 3Associate Professor, Department of Physiology,
    JIPMER, Pondicherry, India, 4Associate Professor, Department of Pulmonology, JIPMER, Pondicherry, India

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Published

2020-03-26

How to Cite

Autonomic Function Tests in Chronic Obstructive Pulmonary Disease (COPD) and their Correlation with Disease Severity. (2020). Indian Journal of Public Health Research & Development, 11(3), 104-109. https://doi.org/10.37506/ijphrd.v11i3.702