Linezolid Resistantclinically Significant Isolates of Coagulase Negative Staphylococci: An Emerging Therapeutic Concern
DOI:
https://doi.org/10.37506/ijphrd.v11i3.829Keywords:
CoNS, S. epidermidis, S.haemolyticus, linezolid, methicillin resistanceAbstract
Multidrug resistant Coagulase Negative Staphylococci (MDRCoNS) have emerged as a major cause of
morbidity and mortality in hospital settings. A total of 706 clinically significant isolates of CoNS, were
identified up to species level. Antimicrobial susceptibility testing was carried out with especial reference
to linezolid and methicillin. Staphylococcus epidermidis (44.33%) was the predominant species isolated
followed by Staphylococcus haemolyticus (39.37%) and Staphylococcus lugdenensis (5.24%). Isolates
were predominantly recovered from blood 82.86%. Linezolid resistance (LzR) was seen in 2.54%.S.
haemolyticuswas the most resistant phenotype. The LzR isolates were also methicillin resistant.
MDRCoNSposes a significant therapeutic challengedemanding judicious use of antibiotics.
