Eradication of Helicobacter Pylori Infection Using Triple Drug  Therapy: A Hospital Based Observational Study in Sikkim

Authors

H pylori, gastric ulcer, eradication, triple regime.

Introduction: Helicobacter pylori infection is the important cause of various gastrointestinal. Variable

resistance to treatment has been reported. This study was conducted to assess eradication rate of h pylori

infection using the standard clarithromycin triple therapy.

Method: This retrospective observational study was conducted in Central Referral Hospital, Sikkim Manipal

Institute of Medical Sciences. 100 consecutive patients in a period of one year from 2016-2017 who were

found positive for H pylori infection by rapid urease test (RUT) or histology or both were included in the

study.Assessment of the eradication of H pylori was carried out after 8 weeks of treatment using 14 days of

clarithromycin containing standard triple regimen.

Results: Out of 100 patients,63 were males and 37 were females. Mean age of the patients was 38 years.

Overall eradication rate was found to 63% after 8 weeks of treatment. Patients with gastric ulcer disease

had worst eradication rate and it was statistically significant.[p=0.0143, OR 4.29(1.33-13.79)] .Out of these

patients, eradication rate for H pylori was higher in duodenal ulcer patients than gastric ulcer patients.

[p=0.0069, OR 6.5(1.6751-25.7798)].We found eradication rate of 63% in our study similar to these

studies.7-10 days of triple therapy containing clarithromycin is reported to have around 90% eradication

rate. (6) Of late, 7-10 days triple therapies have shown unacceptably low cure rates. We found eradication

rate of 63% in our study similar to these studies.

Discussion: Triple therapy, a recommended first-line treatment of H. pylori infection is found to be one

of the most effective eradication in Asia and Africa. Seven days administration of a PPI, amoxicillin or

metronidazole and clarithromycin is well-tolerated and improves patient’s compliance. 7-10 days of triple

therapy containing clarithromycin is reported to have around 90% eradication rate.

Mona Dhakal1 , Om Prakash Dhakal2 , Dhurba Bhandari3

1 Professor in Medicine, 2Professor in Medicine, Department of Medicine, 3Tutor, Department of Microbiology, Sikkim Manipal Institute of Medical Sciences, Gangtok Sikkim