Analysis of Calcium and Phsophate in Patiens with Heart Failure

Abstract

Heart failure is a clinical syndrome caused by abnormalities in the structure or function of the heart in the

myocardium, causing ventricular filling or cardiac output. Calcium and phosphate are metabolic markers that

have been linked to the development of the cardiovascular disease. Increased levels of phosphate in patients

cause increased production of FGF-23 which induces activation of calcineurin signaling in cardiomyocytes

and triggers cardiac hypertrophy. Calcium plays an important role in connecting membrane stimulation with

contractions in the myocardium. This study uses a cross-sectional method. Examination of calcium and

phosphate levels using serum samples was taken on 57 heart failure patients treated at the Integrated Heart

Center Dr. Wahidin Sudirohusodo during the period May to August 2019. Data were analyzed statistically

by the Kolmogorov Smirnov test and the Independent T-test.This study showed a significant difference

between the calcium levels of the ejection fraction group <50% with a median of 4.67 mg / dL and the

ejection fraction group> 50% with a median of 6.06 mg / dL (p <0.01). There was a significant difference

between the phosphate levels of the ejection fraction group <50% with a median of 3.62 mg / dL and the

ejection fraction group> 50% with a median of 3.04 mg / dL (p = 0.04). It was concluded that calcium levels

arehigher in heart failure patients with ejection fraction> 50% & phosphate levels lower in heart failure

patients with ejection fraction> 50%.