Effectiveness of Low-Level Laser Therapy and Low Intensity Pulsed Ultrasound in Sensory Recovery in Experimentally Induced Peripheral Nerve Injury Rat Model

Abstract

Background: Peripheral nerve injuries are known to cause significant functional impairment and diminished
sensory recovery, necessitating the exploration of effective therapeutic interventions.
Purpose: The purpose of this research is to find the effectiveness of low-level laser therapy (LLLT) and low intensity
pulsed ultrasound (LIPUS) sensory recovery in an experimentally induced peripheral nerve injury rat model.
Materials and Methods: In this study, 18 adult male wistar rats which are divided into LLLT (n = 6), LIPUS (n = 6),
and control (n = 6) groups. All rats underwent a standardized procedure to induce peripheral nerve injury, while
the control group received sham procedures. Hot-Plate test and Cold-Plate Tests were conducted for pre- and
post-operative evaluation of sensory recovery at POD 7, 14, 21 days.
Results: The study’s findings revealed that LLLT exhibited significantly improved sensory recovery compared to
LIPUS and control groups on POD 14 and 21, indicating its potential as a promising non-invasive intervention for
managing peripheral nerve injuries (P <0.001).
Conclusion: The study recommends that LLLT is more effective when compared with LIPUS in promoting sensory
recovery and enhancing in a rat model of peripheral nerve injury. Positive outcomes indicate LLLT’s potential as
a promising intervention for managing peripheral nerve injuries.