Estimation of IL-6 and IL-8 in the Urine and Serum of Children with Urinary Tract Infection

Abstract

Urinary tract infection (UTI) is defined as the presence of bacteria in urine along with symptoms of infection.
UTIs occurs in 1.1% of girls and 1.4% of boys in the first year of life. The aim of the study was to assess
the usefulness of measurement of pro-inflammatory interleukin (IL)-6 and IL -8 concentrations in the urine
and serum of children with UTI. A total of Eighty serum sample and seventy tow urine sample have been
collected from children with urinary tract infection, Their age ranged between 33days- 12 years old, fifty six
children of the same age collected as controls .Urine and serum IL-6 and IL-8 concentrations of both groups
were measured and compared. Urine and serum concentrations of IL -8 were significantly higher in children
with UTI compared with controls group (P = 0.0001, P = 0.0002) respectively, while there was no significant
different in urine and serum concentration of IL-6 of children with UTI and controls group(P = 0.1199 , P
=0.572) respectively. The results demonstrate that IL-8 is a good biomarker for urinary tract infection, while
IL-6 is not.